National Security Branch
- Executive Assistant Director – Jay S. Tabb, Jr.
- Counterintelligence Division – Bill Priestap
- Counterterrorism Division – Michael C. McGarrity
- High-Value Detainee Interrogation Group – Eli “Sam” Miranda
- Terrorist Screening Center – Charles H. Kable, IV
- Weapons of Mass Destruction Directorate – Brian Boetig
Criminal, Cyber, Response, and Services Branch
- Executive Assistant Director – Amy Hess
- Criminal Investigative Division – Robert Johnson
- Critical Incident Response Group – Gregory D. Cox
- Cyber Division – Matt Gorham
- International Operations Division – George L. Piro
- Victim Services Division – Kathryn Turman
Intelligence Branch
- Executive Assistant Director – Joshua D. Skule
- Directorate of Intelligence – Stephen Laycock
- Office of Partner Engagement – Kerry Sleeper
- Office of Private Sector – Michael Sullivan
Science and Technology Branch
- Executive Assistant Director – Christopher M. Piehota
- Criminal Justice Information Services Division – Douglas Lindquist
- Laboratory Division – G. Clayton Grigg
- Operational Technology Division – Brian K. Brooks
Information and Technology Branch
- Executive Assistant Director – John S. Adams
- IT Applications and Data Division – Michael Gavin
- IT Enterprise Services Division – Jeremy Wiltz
- IT Infrastructure Division – W. L. Scott Bean, III
Human Resources Branch
- Executive Assistant Director – Andrew W. Vale
- Human Resources Division – David Schlendorf
- Security Division – Gerald "Jerry" Roberts, Jr.
- Training Division – Donald Alway