Many in the galaxy consider themselves atheist or agnostic, considering established religions as archaic and foolish after millennia of scientific discovery and exploration. Still, some felt the desire to think of something greater than themselves, something to guide them and lead them to some higher purpose. Though each acolyte is different according to their unique personalities, all tend to agree that Gods and Goddesses themselves are above mortal notions of "Good" or "Evil."
| Hylax | diplomacy, first contact, friendship, peace |
| Iomedae | honorable battle, humanity, justice, valor |
| Sarenrae | healing, redemption, the sun |
| Yaraesa | knowledge, mental perfection, scholarship, science |
| Desna | dreams, luck, stars, travelers |
| Weydan | discovery, equality, exploration, freedom |
| Abadar | civilization, commerce, law, wealth |
| Talavet | community, self-reliance, tradition |
| Eloritu | history, magic, secrets |
| Ibra | celestial bodies, the cosmos, mysteries of the universe |
| Pharasma | birth, death, fate, prophecy |
| Triune | artificial intelligence, computers, the Drift |
| Besmara | piracy, space monsters, strife |
| Oras | god of adaptation, evolution, natural selection |
| Damoritosh | conquest, duty, war |
| Zon-Kuthon | darkness, envy, loss, pain |
| Lao Shu Po | assassins, rats, spies, thieves |
| Urgathoa | disease, gluttony, undeath |
| Nyarlathotep | conspiracies, dangerous secrets, forbidden magic |
| The Devourer | black holes, destruction, supernovas |
| Arshea | freedom, physical beauty, sexuality |
| Black Butterfly | distance, silence, space |
| Kadrical | collections, order, and preservation |
| Groetus | empty places, oblivion, ruins |
| Asmodeus | contracts, pride, slavery, tyranny |
| Lissala | duty, fate, obedience, reward of service |
| Lamashtu | madness, monsters, nightmares |