The Gangrel clan from Vampire: The Masquerade was recreated for Vampire: The Requiem as one of the five major clans. As archetypal savages, noble and otherwise, Gangrels embody primeval instinct, ferocity and intuitive illumination. Feared, revered and reviled alike by their close relationship with their beasts, which both grants them spiritual insight and clouds their judgement, Gangrel stride the nights as feral savants, nomadic hunters and demonic barbarians.
Gangrel favor the Disciplines of Animalism (control over the beasts of nature and the Beast within man's and vampire's soul), Resilience (supernatural toughness), and Protean (shapeshifting). Gangrel have a unique weakness caused by their close connection to the Beast; their animalistic instincts are drawn close to their surface, clouding more reasoned thought. This is represented mechanically by preventing Gangrel characters from re-rolling tens on rolls requiring Mental attributes, and subtracting ones from the total successes rolled.