The Nosferatu were originally a clan from Vampire: The Masquerade, their flawed blood rendering each of them physically hideous in a unique way (see Nosferatu). The Nosferatu of Vampire: The Requiem have expanded on this weakness, by rendering them disturbing in a different way - rather than a physical deformity, they each have something less obviously inhuman wrong with them, be it a terrible scent, a broken and screeching voice, a sickly pallor, or something less specific. This allows them to interact with mortals without violating the Masquerade, though they still suffer severe social drawbacks, represented mechanically by preventing Nosferatu characters from re-rolling tens, and subtracting ones rolled from the total number of successes.
Nosferatu are often found in less desirable portions of the city, such as the sewers, and are known as "Haunts." The Nosferatu make extensive use of Vigor (inhuman strength), Obfuscate (supernatural stealth), and their unique Discipline, Nightmare, which grants them the ability to tap into the hidden fears of their targets.