A 1975 horror novel by American author Stephen King. It was his second published novel.

Ben Mears, a writer, has returned to Jerusalem's LotMaine, after 25 years to try to write his next novel. He quickly becomes friends with high school teacher Matt Burke and starts a romantic relationship with Susan Norton, a young college graduate with ambitions of leaving town. Ben returned to "the Lot" to write a book about the long-abandoned Marsten House, where he had a bad childhood experience when he saw a hanging ghost. He learns that the house—the former home of Depression-era hitman Hubert "Hubie" Marsten—has been purchased by Kurt Barlow, ostensibly an Austrian immigrant who has arrived in the Lot to open an antique furniture store. Barlow is supposedly on an extended buying trip; only his business partner, Richard Straker, is publicly seen. The truth, however, is that Barlow is an ancient vampire, and Straker is his human familiar.

The duo's arrival coincides with the disappearance of a young boy, Ralphie Glick, and the death of his 12-year-old brother, Danny, who becomes the town's first vampire turned by Barlow. Barlow also turns town dump custodian Dud Rogers and telephone repairman Corey Bryant. Danny turns other locals into vampires, including the graveyard digger, Mike Ryerson, a newborn baby, Randy McDougall, a man named Jack Griffen, and Danny's mother, Marjorie. Danny fails to turn his classmate Mark Petrie, who resists him by holding a plastic cross in Danny's face. To fight the spread of the new vampires, Ben and Susan are joined by Matt Burke and his doctor, Jimmy Cody, along with Mark and the local priest, Father Callahan. Susan is captured by Barlow, who turns her. She is eventually staked through the heart by Ben.

When Father Callahan and Mark go to Mark's house to explain the danger that his family is in, the power is suddenly cut off, and Barlow appears. After killing Mark's parents, Barlow takes the boy hostage. Callahan pulls out his cross to drive him off until Barlow challenges him to throw the cross away. Callahan, not having faith enough to do so, is soon overwhelmed by Barlow, who forces Callahan to drink his blood, making him "unclean." When Callahan tries to re-enter his church, he receives an electric shock, preventing him from going inside. Defeated, Callahan leaves Jerusalem's Lot.

Matt suffers a fatal heart attack, while Jimmy is killed when he falls from a rigged staircase and is impaled by knives set up by the vampires. Ben and Mark destroy Barlow, but they are lucky enough to escape with their lives and are forced to leave the town to the now-leaderless vampires. Ben returns the following day to retrieve and bury the bodies of Mark's parents and Jimmy Cody in a clearing behind the Petrie residence. The novel's prologue, set shortly after the end of the story proper, describes Ben and Mark's flight across the country to a seaside town in Mexico, where they attempt to recover from their ordeal. Mark is received into the Catholic Church by a friendly local priest and confesses for the first time what they have experienced. An epilogue reveals the two return to the town one year later, intending to renew the battle. Knowing that there are too many hiding places for the vampires, Ben starts a brush fire in the nearby woods with the intent of destroying the town.