The first Indominus rex was created by a mad alchemist known as Wu. Wanting to use the same arcane arts that created the chimera he combined the traits of various animals saurian and non-saurian. In the end the creature killed their creator and broke out.
Made with the base of a tyrannosaurus rex they combine traits of countless other theropods, avians, and cuttlefish allowing the creature to have a disturbing level of intelligence and camouflage capabilities.