While the sacred datura root is a poisonous flower that is consumed as part of initiation rituals by the White Legs, the root itself is completely safe to eat and has a restorative effect on the body, often used when poultices are in short supply.
Daturana can be seen as part stimpak and part doctor's bag, since consuming daturana will heal about half of the health of crippled limbs as well as giving some health to the player character, at the cost of a penalty to Agility for a moderate amount of time. It can be crafted at a campfire with a Survival skill of 65. Required items consist of flour, purified water and sacred datura root. Daturana's effects scale with the Survival skill level.