The Special Pathogen Response and Eradication Division (or S.P.R.E.D.) is a special force supplied, trained and commanded by the Department of Knowledge. Its primary purpose is to infiltrate parts of the Oceanykan wilderness, isolated settlements or even urban dwellings where outbreaks of the continent's most notorious endemic diseases occur, then sterilise the zone through unconventional means (extreme violence).
- In the case of Devil Rabies, sterilisation by the use of incendiary weapons is preferred, then performing mass cremations on the now diseased corpses (thus preventing scavenger animals from spreading the disease).
- Against an outbreak of Daemonpox, greater precaution must be taken, and the use of overwhelming firepower is preferred due to the fighting capacity of pox cults. Fire support from the Oceanykan People's Army in the form of artillery strikes or aerial bombardment is recommended in rural regions. On the other hand, usage of the SPRED's ample incendiary armoury is more effective in urban environments.
The SPRED is a natural breeding ground for some of the greatest Federal Special Research Division operatives, who perform similar missions against paranormal threats.