Lands to the South
To the south of the Sword Coast lie ancient nations, a tremendous, forbidding jungle, and all manner of lands destroyed or transformed by magical cataclysms and upheavals. Amid the ruin and the distress in these realms are signs of renewal and hope, as tenacious civilizations and peoples rebuild, reclaim, and create anew.
Amn
A nation led by the representatives of five noble families, Amn is a place where the wealthy rule, openly and without pretense. Shrewd traders and ruthless in business, Amnians believe that the end of a successful transaction is justified by any means, ethical or otherwise. Although the nation is richer by far than even the northern metropolises of Baldur's Gate and Waterdeep, its influence is curtailed by the unwillingness of its rulers to work together in the nation's best interest. The members of the Council of Five are fairly unified and tight-fisted in their control of Amn, but their ability to affect events outside their own borders is limited because they can't agree enough on major matters of foreign policy. The oligarchs utterly control their nation, but beyond the areas that each rules, their families and businesses compete with one another and with the locals of far-flung places.
The use of arcane magic is illegal in Amn, meaning that the only authorized spellcasters in the nation are wielders of divine magic who enjoy the support and patronage of a temple, and users of arcane magic who have been given special dispensation by one of the oligarchs. So pervasive is the sway of Amn's oligarchy that few crimes merit physical punishment but those that involve the use of arcane magic or an offense against one of the council's merchant houses. Other infractions are forgiven after the miscreant makes payment of an appropriate fine.
This southern land has long been the battleground for warring genies. After years of struggling beneath their genasi masters, human slaves arose to follow a Chosen of Ilmater, at first using nonviolent resistance, and then erupting in full rebellion following his disappearance. They overthrew the genie lords of Calimport and Memnon, casting the remaining genies out of the cities and back to their elemental homes or into the depths of the deserts.
Much of Calimshan is a chaotic place dominated by wealth, political influence, and personal power. Many pray for the return of the Chosen and the completion of his work. Others are learning to live together without genie masters, and to grudgingly accept the remaining genasi among them.
The vast, choking jungles of Chult hide what many believe to be great mineral wealth, including large gemstones and veins of ore. Poisonous flora and fauna riddle the jungles, but some still brave the dangers to seek their fortunes. Some of the exotic plants that grow only in Chult fetch high prices in mainland markets. Ruined Mezro stands across the sea from Calimshan, waiting for explorers and its displaced people to cleanse the city of its undead inhabitants and uncover the treasures that lie hidden there.
Eastward along the Chultan peninsula lie the remains of Thindol and Samarach. Despite the apparent fall of both civilizations, Thindol remains infested with yuan-ti, while the illusions cloaking Samarach's mountain passes conceal the activities in that nation.
Situated on a warm plain on the shore of the Great Sea, Dambrath is ruled by nomadic clans of human horse riders who revere Silvanus, Malar, and occasionally Selûne. Given the Dambrathans' history of domination by the Crinti, a ruling caste of half-drow, it is no surprise that they reserve their greatest hatred for the drow.
The clans meet twice a year at a sacred site known as the Hills of the Kings, where dozens of totem sculptures are preserved. At these gatherings, each clan updates its totem with an account of its exploits over the previous seasons. Many Dambrathans seek out lycanthropy as a means of showing reverence for their favored deity and honoring their heritage.
Elfharrow
A blasted near-desert north and east of the North Wall mountains bordering Halruaa, Elfharrow isn't a name bestowed by its residents, but rather the sobriquet that travelers use for this violent region. The tribes of xenophobic elves that claim this area don't hesitate to discourage uninvited guests by any means necessary. A simple group of pilgrims might be scared off with some arrows, while a band of hunters or explorers is likely to be killed outright.
Food is sparse in this region, with the forests long since vanished, and as a result the elves of Elfharrow fiercely protect the herds of animals they have cultivated. The elves have no interest in looting the cities of fallen Lapaliiya, but neither are they willing to allow "adventurers" free access to those lands through their territory.
Once believed destroyed in the conflagration of the Spellplague, Halruaa has largely been restored to the insular, magic-mighty nation it once was. Because of the foresight of their divinations, Halruaan wizards were able to use the raging blue fire that followed Mystra's death to propel their nation safely into the realm of Toril's twin, Abeir (displacing part of that world into the Plane of Shadow).
Now that the events of those times have mostly been undone, the famed Halruaan skyships and waterborne vessels have spread out from their home once again, seeking to establish trading routes and political connections, as well as to learn what has changed of the world in their century of absence.
Far to the south and east of the Sword Coast, the Lake of Steam is more accurately an inland sea, its waters tainted by volcanism and undrinkable. Around its perimeter is a conglomeration of city-states and minor baronies typified by the shifting domains known as the Border Kingdoms. Here, along the southern shore of the lake, explorers and fortune seekers squander their amassed wealth building castles, founding communities, and drawing loyal vassals to them—only to have all those good works disappear within a generation or two. In some cases, one of these realms is fortunate to be saved from its inevitable decline by another group of successful adventurers, who inject enough wealth and wisdom to keep the enterprise going a few more decades.
Luiren
Long the homeland of halflings and thought to be the place where their race had its genesis, Luiren was lost during the Spellplague to a great inundation of the sea. In the century since that great disaster, the waters receded, and now stories told by travelers from the south tell of halfling communities that survived as island redoubts.
Tethyr is a feudal realm ruled by Queen Anais from its capital of Darromar. The queen commands her dukes, who in turn receive homage from the counts and countesses of the realm, appoint sheriffs over their counties, and generally maintain order. The farmlands of Tethyr are abundant, and its markets flow freely with trade from the Western Heartlands.
Tethyr has seen more than its share of noble intrigue and royal murder, and adventurers who are native to Tethyr or merely passing through that land are often drawn into such plots, either as unwitting accomplices or as easy scapegoats.