The Second Inquisition (often shortened to SI) is a term used by the Vampire to describe the global rise in hunter activity targeting them specifically, much of which serves as a continuation of the persecutions of the original Inquisition. The term 'Second Inquisition' is frequently used to refer specifically to the Coalition, despite that conspiracy being only one part of the wider movement (albeit one of greatly outsizes significance). Some conflate the Second Inquisition as a whole with the Hunters' own Reckoning.
The rise of the Second Inquisition has also seen "vampire" exit common Hunter parlance, being mostly replaced with "blankbody", referring to the low body temperature of the undead that marks them as inhuman.