Across the multiverse there exists an infinity of timelines. These alternate universes are not static, they fluctuate like a waves. They also don't all flow in the same direction, leading to some strands of the tapestry hitting each other.
Nexus points are spots in space and time where a large amount of timelines touch each other. Experts have determined that there exists an unseen force that causes these threads to attract each other, leading to a compounding effect where once a critical mass has been reached a nexus forms where more and more threads get pulled in.
This puts an extreme amount of stress on the hosting timeline as it's own laws of existence get constantly altered and eventually the timeline risks getting completely unraveled.
Such worlds are also frequently a constant battlefield as many multiversal organizations use this opportunity to exploit the Rifts, as well as expand their power and influence since not these places can also act as multiversal highways allowing those with the tech necessary to go as they please and reach many other places across the multiverse.