Strange science is the fuel of innovation, it was Hahn, Meitner, and Strassmann's discovery that lead to Oppenheimer's atomic bombs. As such, it would make sense that otherwise mundane people would use science and technology to do what others can do biologically. The people who use such technology for their powers are known as machines, and this is for many reasons. Some are called such because either their power-suit makes them look robotic, or they are a fusion of biology and technology making them part machine. The other is because they use pills and serums to temporarily giving them the strength and durability of a machine.
While many other Powered use technology, like grappling hooks or comms units, a machine is explicitly an individual who uses technology to emulate biological powers. A hero with a power-suit can fly in a similar way to a legacy, or blast energy similar to an alien, or maybe grow and shrink like a mutant.